What is supplement substantiation?

Substantiation is the process of gathering and documenting scientific evidence that supports the health claims you make on your supplement labels and marketing materials. The FDA requires that all structure–function claims be truthful, non-misleading, and substantiated by competent and reliable scientific evidence — typically clinical trials on healthy human subjects.

How does Nutra Comp's AI analysis work?

Nutra Comp searches PubMed for clinical trials relevant to your ingredient, filters for studies on healthy human subjects with oral administration, and uses AI to extract key data: p-values, effect sizes, study design, population details, and conclusions. It distinguishes between across-group and within-group significance and ranks evidence strength with a confidence scoring system.

What data sources does Nutra Comp use?

Nutra Comp primarily searches PubMed/MEDLINE, the world's largest biomedical literature database maintained by the U.S. National Library of Medicine. We focus on peer-reviewed clinical trials, randomised controlled trials (RCTs), meta-analyses, and systematic reviews.

Are the generated claims FDA-compliant?

Yes. Nutra Comp generates structure–function claims in strict accordance with the FDA Small Entity Compliance Guide. All claims avoid explicit and implicit disease references. However, we recommend having your legal/regulatory team review the final output before use, as Nutra Comp is a tool to assist — not replace — professional compliance review.

How long does a typical ingredient search take?

Most ingredient searches complete within 5–15 minutes, depending on the volume of clinical literature available. Compare this to the typical manual process which can take 40–100+ hours per ingredient when done by a human compliance expert.

Can I export my reports?

Absolutely. All clinical evidence reports, structure–function claims, and substantiation memos can be exported as professional PDF documents. These are formatted for easy sharing with your legal team, regulatory reviewers, or business partners.

What does 'ingredient searches per month' mean?

Each search is one ingredient analysis — for example, searching 'Ashwagandha' or 'Vitamin D3'. The search generates a complete evidence report, claims, and substantiation memo for that ingredient. Your monthly allowance resets on your billing date.

When will Nutra Comp be available?

We're currently in private beta. Join the waitlist to get early access and be notified when we launch. Early waitlist members will receive priority access and special launch pricing.

Resveratrol: Clinical Evidence & Substantiation Summary

Clinical Trials

Strongest Evidence

Cardiovascular & Anti-ageing

Typical Dosage

150–500 mg/day (trans-resveratrol)

Common Forms

Trans-resveratrol

What Is Resveratrol?

Resveratrol is a polyphenol found in red grape skins, red wine, and Japanese knotweed. It activates sirtuins and AMPK, with clinical evidence supporting cardiovascular protection, anti-inflammatory effects, and metabolic health.

Mechanism of action: Resveratrol activates SIRT1 (a NAD+-dependent deacetylase involved in longevity pathways), AMPK, and Nrf2 antioxidant pathways. It inhibits NF-κB-mediated inflammation and improves endothelial function via eNOS upregulation and nitric oxide production.

Clinical Evidence Summary

Below are 3 key clinical studies on Resveratrol. Nutra Comp analyses 41+ studies in its full clinical evidence report.

Meta-analysis2018PMID: 29210129

Resveratrol and cardiovascular health: a meta-analysis

Population: 19 RCTs, 1,112 participants

Key finding: Resveratrol significantly improved flow-mediated dilation (FMD: +1.46%, p=0.002) and reduced systolic blood pressure (WMD: -2.1 mmHg).

Meta-analysis2019PMID: 30487456

Resveratrol supplementation and inflammatory markers

Population: 15 RCTs

Key finding: Resveratrol significantly reduced CRP (WMD: -0.54 mg/L, p=0.01) and TNF-α in overweight and diabetic populations.

Meta-analysis2019PMID: 31142457

Resveratrol and glycaemic control in type 2 diabetes

Population: 11 RCTs

Key finding: Resveratrol supplementation improved fasting glucose (WMD: -9.8 mg/dL, p=0.003) and insulin sensitivity (HOMA-IR: -0.52, p=0.01).

Evidence-Based Structure–Function Claims

Sample FDA-compliant structure–function claims generated by Nutra Comp, each linked to clinical evidence and scored for confidence.

“Supports cardiovascular health and healthy blood flow”

Category: Cardiovascular · Confidence: 8/10

“Supports healthy inflammatory response”

Category: Anti-inflammatory · Confidence: 7/10

“Provides antioxidant support through polyphenol activity”

Category: Antioxidant · Confidence: 8/10

Get the full substantiation report for Resveratrol

Includes all 41+ clinical studies analysed, complete claims library, and a ready-to-file substantiation memo.

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Related Ingredients

Coenzyme Q10 (CoQ10)

68 studies · Cardiovascular Health

Quercetin

36 studies · Immune & Anti-inflammatory

Green Tea Extract

86 studies · Metabolic Support

Key Terms

Meta-Analysis Bioavailability Clinical Trial

Frequently Asked Questions

Is resveratrol FDA approved?

Resveratrol is a dietary supplement under DSHEA. It does not require FDA approval. Trans-resveratrol has self-affirmed GRAS status.

What are the most studied benefits?

The strongest evidence supports resveratrol for cardiovascular health (improved blood flow, blood pressure), anti-inflammatory effects, and metabolic health in diabetic populations.

What dosage is used in clinical studies?

Most studies use 150–500 mg/day of trans-resveratrol. Bioavailability is low; micronised and phytosome forms may improve absorption.

Stop Spending Weeks on Substantiation

Nutra Comp generates full clinical evidence reports, FDA-compliant structure–function claims, and substantiation memos in minutes — not months.

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