What Is NMR Identity Testing?
Nuclear Magnetic Resonance (NMR) spectroscopy used to verify the identity and purity of raw ingredients, detecting adulterants and ensuring that what's on the label matches what's in the product.
Why It Matters for Supplement Brands
Ingredient identity and purity testing is required under cGMP regulations. NMR is one of the most reliable methods for confirming ingredient identity and detecting economically motivated adulteration — a growing concern in the supplement industry, particularly for popular botanicals.
How It Works
NMR spectroscopy works by analysing the magnetic properties of atomic nuclei in a compound. Each ingredient produces a unique 'fingerprint' spectrum that can be compared against reference libraries.
NMR can detect: - **Substitution**: Cheaper ingredients swapped for expensive ones - **Adulteration**: Synthetic compounds added to boost potency readings - **Contamination**: Unexpected substances in the raw material - **Degradation**: Changes in the ingredient's chemical profile over time
Under 21 CFR 111.75, manufacturers must verify the identity of dietary ingredients using at least one appropriate test. NMR is considered one of the most comprehensive single-test methods available.
Common Mistakes to Avoid
- ✗Relying solely on cheaper methods like HPTLC when NMR would catch adulterants those methods miss
- ✗Not requiring suppliers to provide identity testing data as part of the supply chain audit
- ✗Assuming that COA documents from suppliers are sufficient without independent verification
Related Terms
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