What is supplement substantiation?

Substantiation is the process of gathering and documenting scientific evidence that supports the health claims you make on your supplement labels and marketing materials. The FDA requires that all structure–function claims be truthful, non-misleading, and substantiated by competent and reliable scientific evidence — typically clinical trials on healthy human subjects.

How does Nutra Comp's AI analysis work?

Nutra Comp searches PubMed for clinical trials relevant to your ingredient, filters for studies on healthy human subjects with oral administration, and uses AI to extract key data: p-values, effect sizes, study design, population details, and conclusions. It distinguishes between across-group and within-group significance and ranks evidence strength with a confidence scoring system.

What data sources does Nutra Comp use?

Nutra Comp primarily searches PubMed/MEDLINE, the world's largest biomedical literature database maintained by the U.S. National Library of Medicine. We focus on peer-reviewed clinical trials, randomised controlled trials (RCTs), meta-analyses, and systematic reviews.

Are the generated claims FDA-compliant?

Yes. Nutra Comp generates structure–function claims in strict accordance with the FDA Small Entity Compliance Guide. All claims avoid explicit and implicit disease references. However, we recommend having your legal/regulatory team review the final output before use, as Nutra Comp is a tool to assist — not replace — professional compliance review.

How long does a typical ingredient search take?

Most ingredient searches complete within 5–15 minutes, depending on the volume of clinical literature available. Compare this to the typical manual process which can take 40–100+ hours per ingredient when done by a human compliance expert.

Can I export my reports?

Absolutely. All clinical evidence reports, structure–function claims, and substantiation memos can be exported as professional PDF documents. These are formatted for easy sharing with your legal team, regulatory reviewers, or business partners.

What does 'ingredient searches per month' mean?

Each search is one ingredient analysis — for example, searching 'Ashwagandha' or 'Vitamin D3'. The search generates a complete evidence report, claims, and substantiation memo for that ingredient. Your monthly allowance resets on your billing date.

When will Nutra Comp be available?

We're currently in private beta. Join the waitlist to get early access and be notified when we launch. Early waitlist members will receive priority access and special launch pricing.

Hyaluronic Acid: Clinical Evidence & Substantiation Summary

Clinical Trials

Strongest Evidence

Skin & Joint Health

Typical Dosage

120–240 mg/day

Common Forms

Sodium hyaluronate

What Is Hyaluronic Acid?

Hyaluronic acid (HA) is a high-molecular-weight glycosaminoglycan found throughout the connective, epithelial, and neural tissues. While famous as a topical, oral HA has significant evidence for joint comfort and skin hydration.

Mechanism of action: Oral HA is absorbed in the gut and distributed to tissues via the lymph and blood. It acts as a lubricant and shock absorber in synovial fluid and increases the water-holding capacity of the extracellular matrix in the skin.

Clinical Evidence Summary

Below are 3 key clinical studies on Hyaluronic Acid. Nutra Comp analyses 38+ studies in its full clinical evidence report.

Systematic review2017PMID: 28747444

Oral hyaluronic acid for skin hydration: systematic review

Population: 14 clinical studies

Key finding: Oral HA (120–240 mg/day) significantly improved skin moisture content and reduced dryness and wrinkles over 8–12 weeks (p<0.05).

Systematic review and meta-analysis2015PMID: 26211634

Oral HA for knee osteoarthritis: Cochrane review

Population: 13 RCTs

Key finding: Oral hyaluronic acid significantly reduced knee pain (VAS score) and improved physical function compared to placebo in mild-to-moderate OA.

Clinical tracer study2020PMID: 32432219

Bioavailability of oral hyaluronic acid

Population: Healthy adults

Key finding: Orally administered HA is broken down by gut bacteria and absorbed as fragments, with significant accumulation in the skin and joints within 24 hours.

Evidence-Based Structure–Function Claims

Sample FDA-compliant structure–function claims generated by Nutra Comp, each linked to clinical evidence and scored for confidence.

“Supports healthy skin hydration and elasticity”

Category: Skin · Confidence: 9/10

“Supports joint comfort and lubrication”

Category: Joint Health · Confidence: 8/10

“Supports healthy connective tissue integrity”

Category: Joint Health · Confidence: 7/10

Get the full substantiation report for Hyaluronic Acid

Includes all 38+ clinical studies analysed, complete claims library, and a ready-to-file substantiation memo.

Join Waitlist for Full Access

Related Ingredients

Collagen Peptides

41 studies · Skin Health

Glucosamine

78 studies · Joint Health

Chondroitin Sulfate

53 studies · Joint Health

Key Terms

Bioavailability Standardised Extract Clinically Effective Dose

Frequently Asked Questions

Is oral hyaluronic acid effective?

Yes. Contrary to early skepticism, clinical trials show that oral HA is absorbed and reaches the peripheral tissues, providing significant benefits for skin moisture and joint pain.

Is hyaluronic acid FDA approved?

HA is sold as a dietary supplement. It is also FDA approved as an injectable medical device (viscosupplementation) for knee osteoarthritis.

What is the difference between high and low molecular weight?

High molecular weight (HMW) HA is the natural form; low molecular weight (LMW) may have faster absorption but sometimes different inflammatory signaling. Most clinical studies use a standardized oral blend.

Stop Spending Weeks on Substantiation

Nutra Comp generates full clinical evidence reports, FDA-compliant structure–function claims, and substantiation memos in minutes — not months.

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