What is supplement substantiation?

Substantiation is the process of gathering and documenting scientific evidence that supports the health claims you make on your supplement labels and marketing materials. The FDA requires that all structure–function claims be truthful, non-misleading, and substantiated by competent and reliable scientific evidence — typically clinical trials on healthy human subjects.

How does Nutra Comp's AI analysis work?

Nutra Comp searches PubMed for clinical trials relevant to your ingredient, filters for studies on healthy human subjects with oral administration, and uses AI to extract key data: p-values, effect sizes, study design, population details, and conclusions. It distinguishes between across-group and within-group significance and ranks evidence strength with a confidence scoring system.

What data sources does Nutra Comp use?

Nutra Comp primarily searches PubMed/MEDLINE, the world's largest biomedical literature database maintained by the U.S. National Library of Medicine. We focus on peer-reviewed clinical trials, randomised controlled trials (RCTs), meta-analyses, and systematic reviews.

Are the generated claims FDA-compliant?

Yes. Nutra Comp generates structure–function claims in strict accordance with the FDA Small Entity Compliance Guide. All claims avoid explicit and implicit disease references. However, we recommend having your legal/regulatory team review the final output before use, as Nutra Comp is a tool to assist — not replace — professional compliance review.

How long does a typical ingredient search take?

Most ingredient searches complete within 5–15 minutes, depending on the volume of clinical literature available. Compare this to the typical manual process which can take 40–100+ hours per ingredient when done by a human compliance expert.

Can I export my reports?

Absolutely. All clinical evidence reports, structure–function claims, and substantiation memos can be exported as professional PDF documents. These are formatted for easy sharing with your legal team, regulatory reviewers, or business partners.

What does 'ingredient searches per month' mean?

Each search is one ingredient analysis — for example, searching 'Ashwagandha' or 'Vitamin D3'. The search generates a complete evidence report, claims, and substantiation memo for that ingredient. Your monthly allowance resets on your billing date.

When will Nutra Comp be available?

We're currently in private beta. Join the waitlist to get early access and be notified when we launch. Early waitlist members will receive priority access and special launch pricing.

Chlorella: Clinical Evidence & Substantiation Summary

Clinical Trials

Strongest Evidence

Detoxification & Immune

Typical Dosage

2–10 g/day

Common Forms

Broken cell wall chlorella

What Is Chlorella?

Chlorella is a single-celled green freshwater algae rich in chlorophyll, protein, vitamins, and minerals. Clinical evidence supports its effects on detoxification, immune function, and cholesterol management.

Mechanism of action: Chlorella's broken cell wall exposes nutrients including chlorophyll (supports detoxification via metalloporphyrin binding), beta-glucans (activate innate immunity via Dectin-1 receptors), and Chlorella Growth Factor (nucleotide-peptide complex supporting cell repair).

Clinical Evidence Summary

Below are 3 key clinical studies on Chlorella. Nutra Comp analyses 21+ studies in its full clinical evidence report.

Meta-analysis2019PMID: 31142457

Chlorella supplementation and lipid profile: a meta-analysis

Population: 9 RCTs, 543 participants

Key finding: Chlorella supplementation significantly reduced total cholesterol (WMD: -15.2 mg/dL, p=0.003) and LDL (WMD: -8.7 mg/dL, p=0.02).

RCT, double-blind2019PMID: 30547890

Chlorella and immune function in healthy adults

Population: 56 adults

Key finding: 5 g/day chlorella for 8 weeks significantly increased salivary IgA secretion rate and NK cell activity versus placebo (p<0.05).

Clinical trial2018PMID: 29099763

Chlorella and heavy metal detoxification

Population: 35 adults with dental amalgam

Key finding: Chlorella supplementation (6 g/day) enhanced urinary mercury excretion by 38% and reduced blood mercury levels over 3 months (p<0.05).

Evidence-Based Structure–Function Claims

Sample FDA-compliant structure–function claims generated by Nutra Comp, each linked to clinical evidence and scored for confidence.

“Supports the body's natural detoxification processes”

Category: Detoxification · Confidence: 7/10

“Supports healthy immune system function”

Category: Immune · Confidence: 7/10

“Provides comprehensive whole-food nutritional support”

Category: Nutrition · Confidence: 7/10

Get the full substantiation report for Chlorella

Includes all 21+ clinical studies analysed, complete claims library, and a ready-to-file substantiation memo.

Join Waitlist for Full Access

Related Ingredients

Vitamin C

168 studies · Immune Function

Green Tea Extract

86 studies · Metabolic Support

Spirulina

35 studies · Lipid & Metabolic Support

Key Terms

Randomised Controlled Trial (RCT)Certificate of Analysis (COA)Third-Party Testing

Frequently Asked Questions

Is chlorella FDA approved?

Chlorella has GRAS status and is sold as a dietary supplement. Broken cell wall processing is essential for nutrient absorption.

What's the difference between chlorella and spirulina?

Chlorella is a green algae with more chlorophyll, while spirulina is a cyanobacterium with more phycocyanin. Chlorella has stronger detoxification evidence; spirulina has stronger lipid-lowering evidence.

What dosage is used in clinical studies?

Most studies use 2–10 g/day. The immune study used 5 g/day. The detoxification study used 6 g/day.

Stop Spending Weeks on Substantiation

Nutra Comp generates full clinical evidence reports, FDA-compliant structure–function claims, and substantiation memos in minutes — not months.

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