What is supplement substantiation?

Substantiation is the process of gathering and documenting scientific evidence that supports the health claims you make on your supplement labels and marketing materials. The FDA requires that all structure–function claims be truthful, non-misleading, and substantiated by competent and reliable scientific evidence — typically clinical trials on healthy human subjects.

How does Nutra Comp's AI analysis work?

Nutra Comp searches PubMed for clinical trials relevant to your ingredient, filters for studies on healthy human subjects with oral administration, and uses AI to extract key data: p-values, effect sizes, study design, population details, and conclusions. It distinguishes between across-group and within-group significance and ranks evidence strength with a confidence scoring system.

What data sources does Nutra Comp use?

Nutra Comp primarily searches PubMed/MEDLINE, the world's largest biomedical literature database maintained by the U.S. National Library of Medicine. We focus on peer-reviewed clinical trials, randomised controlled trials (RCTs), meta-analyses, and systematic reviews.

Are the generated claims FDA-compliant?

Yes. Nutra Comp generates structure–function claims in strict accordance with the FDA Small Entity Compliance Guide. All claims avoid explicit and implicit disease references. However, we recommend having your legal/regulatory team review the final output before use, as Nutra Comp is a tool to assist — not replace — professional compliance review.

How long does a typical ingredient search take?

Most ingredient searches complete within 5–15 minutes, depending on the volume of clinical literature available. Compare this to the typical manual process which can take 40–100+ hours per ingredient when done by a human compliance expert.

Can I export my reports?

Absolutely. All clinical evidence reports, structure–function claims, and substantiation memos can be exported as professional PDF documents. These are formatted for easy sharing with your legal team, regulatory reviewers, or business partners.

What does 'ingredient searches per month' mean?

Each search is one ingredient analysis — for example, searching 'Ashwagandha' or 'Vitamin D3'. The search generates a complete evidence report, claims, and substantiation memo for that ingredient. Your monthly allowance resets on your billing date.

When will Nutra Comp be available?

We're currently in private beta. Join the waitlist to get early access and be notified when we launch. Early waitlist members will receive priority access and special launch pricing.

Ginkgo Biloba: Clinical Evidence & Substantiation Summary

Clinical Trials

122

Strongest Evidence

Brain Health & Circulation

Typical Dosage

120–240 mg/day

Common Forms

Ginkgo biloba extract (EGb 761)

What Is Ginkgo Biloba?

Ginkgo biloba is one of the oldest living tree species and its leaf extract is one of the most researched herbal supplements for cognitive health and peripheral circulation support.

Mechanism of action: Ginkgo's active components (flavonoids and terpenoids) improve blood flow by reducing blood viscosity and enhancing nitric oxide-mediated vasodilation. It also acts as an antioxidant and modulates several neurotransmitter systems, including acetylcholine and dopamine.

Clinical Evidence Summary

Below are 3 key clinical studies on Ginkgo Biloba. Nutra Comp analyses 122+ studies in its full clinical evidence report.

Meta-analysis2015PMID: 25611164

Ginkgo biloba (EGb 761) and cognitive decline: meta-analysis

Population: 9 RCTs, 2,561 patients

Key finding: Ginkgo (240 mg/day) significantly improved cognitive function and activities of daily living (p<0.001) in individuals with early-stage cognitive impairment.

Systematic review2018PMID: 30154332

Ginkgo and peripheral arterial disease: systematic review

Population: 11 RCTs

Key finding: Ginkgo extract significantly increased pain-free walking distance in patients with intermittent claudication (p<0.05) compared to placebo.

RCT crossover2020PMID: 32432219

Ginkgo and eye health (Glaucoma)

Population: 27 patients

Key finding: Ginkgo supplementation for 4 weeks significantly improved pre-existing visual field defects (p=0.04), likely through improved ocular blood flow.

Evidence-Based Structure–Function Claims

Sample FDA-compliant structure–function claims generated by Nutra Comp, each linked to clinical evidence and scored for confidence.

“Supports healthy blood flow and peripheral circulation”

Category: Cardiovascular · Confidence: 9/10

“Supports healthy memory and cognitive performance”

Category: Cognitive · Confidence: 8/10

“Supports healthy ocular blood flow”

Category: Vision · Confidence: 7/10

Get the full substantiation report for Ginkgo Biloba

Includes all 122+ clinical studies analysed, complete claims library, and a ready-to-file substantiation memo.

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Related Ingredients

L-Theanine

28 studies · Relaxation & Focus

Coenzyme Q10 (CoQ10)

68 studies · Cardiovascular Health

Phosphatidylserine

24 studies · Cognitive Function

Key Terms

Randomised Controlled Trial (RCT)Meta-Analysis Standardised Extract

Frequently Asked Questions

Is ginkgo biloba FDA approved?

Ginkgo is sold as a dietary supplement. In several European countries, specific Ginkgo extracts (EGb 761) are registered drugs for the treatment of cognitive impairment and peripheral arterial disease. It is not FDA approved as a drug in the US.

Does ginkgo interact with blood thinners?

Yes. Due to its blood-thinning effects, Ginkgo should be used with caution by individuals taking anticoagulant or antiplatelet medications (like warfarin or aspirin).

How long until I see effects?

Improvements in circulation and cognitive scores typically require 4 to 8 weeks of consistent daily use.

Stop Spending Weeks on Substantiation

Nutra Comp generates full clinical evidence reports, FDA-compliant structure–function claims, and substantiation memos in minutes — not months.

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